James H. Cole | MANIFOLD Lab

Association of Brain Age With Physical Disability and Cognitive Impairment in People With Multiple Sclerosis of the Same Age

Thu, 01 Jan 2026 00:00:00 +0000

Author Response: Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain Age

Wed, 01 Jan 2025 00:00:00 +0000

Authors: Sivaniya Subramaniapillai, James H. Cole, Ann-Marie G. de Lange

DOI: https://doi.org/10.1212/wnl.0000000000210221

Brain-age in ultra-low-field MRI: how well does it work?

Wed, 01 Jan 2025 00:00:00 +0000

Authors: Francesca Biondo, Carly Bennallick, Sophie A. Martin, Lemuel Puglisi, Thomas C. Booth, David A. Wood, Juan Eugenio Iglesias, František Váša, James H. Cole

DOI: https://doi.org/10.1101/2025.10.19.25338298

Estimating white matter hyperintensities volume in individuals with stroke using T1-weighted images

Wed, 01 Jan 2025 00:00:00 +0000

Authors: Mahir H. Khan, Stuti Chakraborty, Jennifer K. Ferris, Lara A. Boyd, Mohamed Salah Khlif, Amy Brodtmann, Michael R. Borich, James H. Cole, Steven C. Cramer, Niko H. Fullmer, Jeanette R. Gumarang, Hosung Kim, Amisha Kumar, Octavio Marin-Pardo, Susan M. Murphy, Emily R. Rosario, Heidi M. Schambra, Grace C. Song, Sook-Lei Liew

DOI: https://doi.org/10.1101/2025.10.22.25338564

Explainable artificial intelligence for neuroimaging-based dementia diagnosis and prognosis

Wed, 01 Jan 2025 00:00:00 +0000

Authors: Sophie A. Martin, An Zhao, Jiongqi Qu, Phoebe Imms, Andrei Irimia, Frederik Barkhof, James H. Cole

DOI: https://doi.org/10.1101/2025.01.13.25320382

Latent Representations of Early Brain Development: A Multivariate Normative Model of Brain Structure and Behaviour

Wed, 01 Jan 2025 00:00:00 +0000

Authors: Mariam Zabihi, Francesca Biondo, Jonathan O’Muircheartaigh, Thomas Wolfers, Sean Deoni, Andre Marquand, Muriel M.K. Bruchhage, James H. Cole

DOI: https://doi.org/10.1101/2025.08.14.668769

Regional brain aging patterns reveal disease-specific pathways of neurodegeneration

Wed, 01 Jan 2025 00:00:00 +0000

Authors: Pál Vakli, Béla Weiss, Attila Keresztes, Petra Hermann, James H. Cole, Zoltán Vidnyánszky

DOI: https://doi.org/10.1101/2025.11.12.25339989

SLaM Image Bank – a real-world diverse London cohort linking brain MRI to electronic mental health and dementia records for the development of clinical decision support tools using artificial intelligence

Wed, 01 Jan 2025 00:00:00 +0000

Authors: Ashwin V. Venkataraman, Paul Wright, Amelia Jewell, Christopher Webb, Yini Zhang, Soha K. Patil, M. Jorge Cardoso, James H. Cole, Matthew J. Kempton, Charles R. Marshall, Mitul A. Mehta, Christoph Mueller, Timothy R. Nicholson, Thomas A. Pollak, Timothy Rittman, Zeynep Sahin, Ana B. Solana, Daniel R. Stahl, František Váša, Allan H Young, Steve Williams, Robert Stewart, Dag Aarsland

DOI: https://doi.org/10.1101/2025.01.07.25319950

Structural similarity networks reveal brain vulnerability in dementia

Wed, 01 Jan 2025 00:00:00 +0000

Authors: Marcella Montagnese, Amir Ebneabbasi, Natalia García‐San‐Martín, Clara Pecci‐Terroba, Rafael Romero‐García, Sarah E. Morgan, James H. Cole, Jakob Seidlitz, Timothy Rittman, Richard A. I. Bethlehem

DOI: https://doi.org/10.1002/alz.70973

WITHDRAWN: BabyPy: a brain-age model for infancy, childhood, and adolescence

Wed, 01 Jan 2025 00:00:00 +0000

Authors: Francesca Biondo, Jonathan O’Muircheartaigh, Richard A.I. Bethlehem, Jakob Seidlitz, Aaron Alexander-Bloch, Jed T. Elison, Viren D’Sa, Sean C.L. Deoni, Muriel M.K. Bruchhage, James H. Cole

DOI: https://doi.org/10.1101/2025.02.05.636598

Brain age is longitudinally associated with sensorimotor impairment and mild cognitive impairment in subacute stroke

Mon, 01 Jan 2024 00:00:00 +0000

Authors: Octavio Marin-Pardo, Mahir H. Khan, Stuti Chakraborty, Michael R. Borich, Mayerly Castillo, James H. Cole, Steven C. Cramer, Miranda R. Donnelly, Emily E. Fokas, Niko H. Fullmer, Jeanette R. Gumarang, Leticia Hayes, Hosung Kim, Amisha Kumar, Emily. A. Marks, Emily R. Rosario, Heidi M. Schambra, Nicolas Schweighofer, Grace C. Song, Myriam Taga, Bethany P. Tavenner, Carolee Winstein, Sook-Lei Liew

DOI: https://doi.org/10.1101/2024.12.18.24319276

Greater lesion damage is bidirectionally related with accelerated brain aging after stroke

Mon, 01 Jan 2024 00:00:00 +0000

Authors: Mahir H. Khan, Octavio Marin-Pardo, Stuti Chakraborty, Michael R. Borich, Mayerly Castillo, James H. Cole, Steven C. Cramer, Miranda R. Donnelly, Emily E. Fokas, Niko H. Fullmer, Jeanette R. Gumarang, Leticia Hayes, Hosung Kim, Amisha Kumar, Emily A. Marks, Emily R. Rosario, Heidi M. Schambra, Nicolas Schweighofer, Grace C. Song, Myriam Taga, Bethany P. Tavener, Carolee J. Winstein, Sook-Lei Liew

DOI: https://doi.org/10.1101/2024.12.13.24319014

Personalizing progressive changes to brain structure in Alzheimer's disease using normative modeling

Mon, 01 Jan 2024 00:00:00 +0000

Authors: Serena Verdi, Saige Rutherford, Charlotte Fraza, Duygu Tosun, Andre Altmann, Lars Lau Raket, Jonathan M. Schott, Andre F. Marquand, James H. Cole

DOI: https://doi.org/10.1002/alz.14174

Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients

Mon, 01 Jan 2024 00:00:00 +0000

Authors: Jennifer G. Cox, James H. Cole, Matthew J. Kempton, Steven C. R. Williams, Marius de Groot

DOI: https://doi.org/10.1038/s41598-024-83559-1

Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke

Sun, 01 Jan 2023 00:00:00 +0000

Authors: Sook-Lei Liew, Nicolas Schweighofer, James H. Cole, Artemis Zavaliangos-Petropulu, Bethany P. Tavenner, Laura K.M. Han, Tim Hahn, Lianne Schmaal, Miranda R. Donnelly, Jessica N. Jeong, Zhizhuo Wang, Aisha Abdullah, Jun H. Kim, Alexandre Hutton, Giuseppe Barisano, Michael R. Borich, Lara A. Boyd, Amy Brodtmann, Cathrin M. Buetefisch, Winston D. Byblow, Jessica M. Cassidy, Charalambos C. Charalambous, Valentina Ciullo, Adriana Bastos Conforto, Rosalia Dacosta-Aguayo, Julie A. DiCarlo, Martin Domin, Adrienne N. Dula, Natalia Egorova-Brumley, Wuwei Feng, Fatemeh Geranmayeh, Chris M. Gregory, Colleen A. Hanlon, Kathryn Hayward, Jess A. Holguin, Brenton Hordacre, Neda Jahanshad, Steven A. Kautz, Mohamed Salah Khlif, Hosung Kim, Amy Kuceyeski, David J. Lin, Jingchun Liu, Martin Lotze, Bradley J. MacIntosh, John L. Margetis, Maria Mataro, Feroze B. Mohamed, Emily R. Olafson, Gilsoon Park, Fabrizio Piras, Kate P. Revill, Pamela Roberts, Andrew D. Robertson, Nerses Sanossian, Heidi M. Schambra, Na Jin Seo, Surjo R. Soekadar, Gianfranco Spalletta, Cathy M. Stinear, Myriam Taga, Wai Kwong Tang, Greg T. Thielman, Daniela Vecchio, Nick S. Ward, Lars T. Westlye, Carolee J. Winstein, George F. Wittenberg, Steven L. Wolf, Kristin A. Wong, Chunshui Yu, Steven C. Cramer, Paul M. Thompson

DOI: https://doi.org/10.1212/wnl.0000000000207219

Brain-predicted age difference estimated using DeepBrainNet is significantly associated with pain and function—a multi-institutional and multiscanner study

Sun, 01 Jan 2023 00:00:00 +0000

Authors: Pedro A. Valdes-Hernandez, Chavier Laffitte Nodarse, Alisa J. Johnson, Soamy Montesino-Goicolea, Vishnu Bashyam, Christos Davatzikos, Julio A. Peraza, James H. Cole, Zhiguang Huo, Roger B. Fillingim, Yenisel Cruz-Almeida

DOI: https://doi.org/10.1097/j.pain.0000000000002984

Comparison of volumetric brain analysis in subjects with rheumatoid arthritis and ulcerative colitis

Sun, 01 Jan 2023 00:00:00 +0000

Authors: Jennifer G. Cox, Marius de Groot, Matthew J. Kempton, Steven C. R. Williams, James H. Cole

DOI: https://doi.org/10.1101/2023.03.08.23286980

Factors affecting the labelling accuracy of brain MRI studies relevant for deep learning abnormality detection

Sun, 01 Jan 2023 00:00:00 +0000

Authors: Matthew Benger, David A. Wood, Sina Kafiabadi, Aisha Al Busaidi, Emily Guilhem, Jeremy Lynch, Matthew Townend, Antanas Montvila, Juveria Siddiqui, Naveen Gadapa, Gareth Barker, Sebastian Ourselin, James H. Cole, Thomas C. Booth

DOI: https://doi.org/10.3389/fradi.2023.1251825

General dimensions of human brain morphometry inferred from genome‐wide association data

Sun, 01 Jan 2023 00:00:00 +0000

Authors: Anna E. Fürtjes, Ryan Arathimos, Jonathan R. I. Coleman, James H. Cole, Simon R. Cox, Ian J. Deary, Javier de la Fuente, James W. Madole, Elliot M. Tucker‐Drob, Stuart J. Ritchie

DOI: https://doi.org/10.1002/hbm.26283

Interpretable machine learning for dementia: A systematic review

Sun, 01 Jan 2023 00:00:00 +0000

Authors: Sophie A. Martin, Florence J. Townend, Frederik Barkhof, James H. Cole

DOI: https://doi.org/10.1002/alz.12948

Personalising Alzheimer’s Disease progression using brain atrophy markers

Sun, 01 Jan 2023 00:00:00 +0000

Authors: Serena Verdi, Saige Rutherford, Charlotte Fraza, Duygu Tosun, Andre Altmann, Lars Lau Raket, Jonathan M. Schott, Andre F. Marquand, James H. Cole

DOI: https://doi.org/10.1101/2023.06.15.23291418

Revealing Individual Neuroanatomical Heterogeneity in Alzheimer Disease Using Neuroanatomical Normative Modeling

Sun, 01 Jan 2023 00:00:00 +0000

The value of arterial spin labelling perfusion MRI in brain age prediction

Sun, 01 Jan 2023 00:00:00 +0000

Authors: Mathijs B. J. Dijsselhof, Michelle Barboure, Michael Stritt, Wibeke Nordhøy, Alle Meije Wink, Dani Beck, Lars T. Westlye, James H. Cole, Frederik Barkhof, Henk J. M. M. Mutsaerts, Jan Petr

DOI: https://doi.org/10.1002/hbm.26242

A meta-analysis of structural MRI studies of the brain in systemic lupus erythematosus (SLE)

Sat, 01 Jan 2022 00:00:00 +0000

Authors: Jennifer G. Cox, Marius de Groot, James H. Cole, Steven C. R. Williams, Matthew J. Kempton

DOI: https://doi.org/10.1007/s10067-022-06482-8

Accurate brain‐age models for routine clinical MRI examinations

Sat, 01 Jan 2022 00:00:00 +0000

Authors: David A. Wood, Sina Kafiabadi, Ayisha Al Busaidi, Emily Guilhem, Antanas Montvila, Jeremy Lynch, Matthew Townend, Siddharth Agarwal, Asif Mazumder, Gareth J. Barker, Sebastien Ourselin, James H. Cole, Thomas C. Booth

DOI: https://doi.org/10.1016/j.neuroimage.2022.118871

An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling

Sat, 01 Jan 2022 00:00:00 +0000

Authors: Tim Hahn, Jan Ernsting, Nils R. Winter, Vincent Holstein, Ramona Leenings, Marie Beisemann, Lukas Fisch, Kelvin Sarink, Daniel Emden, Nils Opel, Ronny Redlich, Jonathan Repple, Dominik Grotegerd, Susanne Meinert, Jochen G. Hirsch, Thoralf Niendorf, Beate Endemann, Fabian Bamberg, Thomas Kröncke, Robin Bülow, Henry Völzke, Oyunbileg von Stackelberg, Ramona Felizitas Sowade, Lale Umutlu, Börge Schmidt, Svenja Caspers, Harald Kugel, Tilo Kircher, Benjamin Risse, Christian Gaser, James H. Cole, Udo Dannlowski, Klaus Berger

DOI: https://doi.org/10.1126/sciadv.abg9471

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

Sat, 01 Jan 2022 00:00:00 +0000

Authors: Constantinos Constantinides, Laura K. M. Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M. Díaz-Caneja, Gary Donohoe, Stefan Du Plessis, Jesse Edmond, Stefan Ehrlich, Robin Emsley, Lisa T. Eyler, Paola Fuentes-Claramonte, Foivos Georgiadis, Melissa Green, Amalia Guerrero-Pedraza, Minji Ha, Tim Hahn, Frans A. Henskens, Laurena Holleran, Stephanie Homan, Philipp Homan, Neda Jahanshad, Joost Janssen, Ellen Ji, Stefan Kaiser, Vasily Kaleda, Minah Kim, Woo-Sung Kim, Matthias Kirschner, Peter Kochunov, Yoo Bin Kwak, Jun Soo Kwon, Irina Lebedeva, Jingyu Liu, Patricia Mitchie, Stijn Michielse, David Mothersill, Bryan Mowry, Víctor Ortiz-García de la Foz, Christos Pantelis, Giulio Pergola, Fabrizio Piras, Edith Pomarol-Clotet, Adrian Preda, Yann Quidé, Paul E. Rasser, Kelly Rootes-Murdy, Raymond Salvador, Marina Sangiuliano, Salvador Sarró, Ulrich Schall, André Schmidt, Rodney J. Scott, Pierluigi Selvaggi, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia I. Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutiérrez, Therese van Amelsvoort, Javier Vázquez-Bourgon, Daniela Vecchio, Aristotle Voineskos, Cynthia S. Weickert, Thomas Weickert, Paul M. Thompson, Lianne Schmaal, Theo G. M. van Erp, Jessica Turner, James H. Cole, Rosa Ayesa-Arriola, Stefan Du Plessis, Yoo Bin Kwak, Víctor Ortiz-García de la Foz, Therese van Amelsvoort, Theo G. M. van Erp, Danai Dima, Esther Walton

DOI: https://doi.org/10.1038/s41380-022-01897-w

Deep learning models for triaging hospital head MRI examinations

Sat, 01 Jan 2022 00:00:00 +0000

DOI: https://doi.org/10.1016/j.media.2022.102391

Global brain health modulates the impact of lesion damage on post-stroke sensorimotor outcomes

Sat, 01 Jan 2022 00:00:00 +0000

Authors: Sook-Lei Liew, Nicolas Schweighofer, James H. Cole, Artemis Zavaliangos-Petropulu, Bethany P. Lo, Laura K.M. Han, Tim Hahn, Lianne Schmaal, Miranda R. Donnelly, Jessica N. Jeong, Zhizhuo Wang, Aisha Abdullah, Jun H. Kim, Alexandre Hutton, Giuseppe Barisano, Michael R. Borich, Lara A. Boyd, Amy Brodtmann, Cathrin M. Buetefisch, Winston D. Byblow, Jessica M. Cassidy, Charalambos C. Charalambous, Valentina Ciullo, Adriana B. Conforto, Rosalia Dacosta-Aguayo, Julie A. DiCarlo, Martin Domin, Adrienne N. Dula, Natalia Egorova-Brumley, Wuwei Feng, Fatemeh Geranmayeh, Chris M. Gregory, Colleen A. Hanlon, Jess A. Holguin, Brenton Hordacre, Neda Jahanshad, Steven A. Kautz, Mohamed Salah Khlif, Hosung Kim, Amy Kuceyeski, David J. Lin, Jingchun Liu, Martin Lotze, Bradley J. MacIntosh, John L. Margetis, Maria Mataro, Feroze B. Mohamed, Emily R. Olafson, Gilsoon Park, Fabrizio Piras, Kate P. Revill, Pamela Roberts, Andrew D. Robertson, Nerses Sanossian, Heidi M. Schambra, Na Jin Seo, Surjo R. Soekadar, Gianfranco Spalletta, Cathy M. Stinear, Myriam Taga, Wai Kwong Tang, Greg T. Thielman, Daniela Vecchio, Nick S. Ward, Lars T. Westlye, Carolee J. Winstein, George F. Wittenberg, Steven L. Wolf, Kristin A. Wong, Chunshui Yu, Steven C. Cramer, Paul M. Thompson

DOI: https://doi.org/10.1101/2022.04.27.489791

Revealing Individual Neuroanatomical Heterogeneity in Alzheimer’s Disease

Sat, 01 Jan 2022 00:00:00 +0000

Authors: Serena Verdi, Seyed Mostafa Kia, Keir Yong, Duygu Tosun, Jonathan M. Schott, Andre F. Marquand, James H. Cole

DOI: https://doi.org/10.1101/2022.06.30.22277053

Sex differences in predictors and regional patterns of brain age gap estimates

Sat, 01 Jan 2022 00:00:00 +0000

Authors: Nicole Sanford, Ruiyang Ge, Mathilde Antoniades, Amirhossein Modabbernia, Shalaila S. Haas, Heather C. Whalley, Liisa Galea, Sebastian G. Popescu, James H. Cole, Sophia Frangou

DOI: https://doi.org/10.1002/hbm.25983

Tissue volume estimation and age prediction using rapid structural brain scans

Sat, 01 Jan 2022 00:00:00 +0000

Authors: Harriet Hobday, James H. Cole, Ryan A. Stanyard, Richard E. Daws, Vincent Giampietro, Owen O’Daly, Robert Leech, František Váša

DOI: https://doi.org/10.1101/2022.01.19.476615

Brain-age predicts subsequent dementia in memory clinic patients

Fri, 01 Jan 2021 00:00:00 +0000

Authors: Francesca Biondo, Amelia Jewell, Megan Pritchard, Dag Aarsland, Claire J. Steves, Christoph Mueller, James H. Cole

DOI: https://doi.org/10.1101/2021.04.03.21254781

Deep learning to automate the labelling of head MRI datasets for computer vision applications

Fri, 01 Jan 2021 00:00:00 +0000

Authors: David A. Wood, Sina Kafiabadi, Aisha Al Busaidi, Emily L. Guilhem, Jeremy Lynch, Matthew K. Townend, Antanas Montvila, Martin Kiik, Juveria Siddiqui, Naveen Gadapa, Matthew D. Benger, Asif Mazumder, Gareth Barker, Sebastian Ourselin, James H. Cole, Thomas C. Booth

DOI: https://doi.org/10.1007/s00330-021-08132-0

Distributional Gaussian Process Layers for Outlier Detection in Image Segmentation

Fri, 01 Jan 2021 00:00:00 +0000

Authors: Sebastian G. Popescu, David J. Sharp, James H. Cole, Konstantinos Kamnitsas, Ben Glocker

DOI: https://doi.org/10.1007/978-3-030-78191-0_32

Editorial: Predicting Chronological Age From Structural Neuroimaging: The Predictive Analytics Competition 2019

Fri, 01 Jan 2021 00:00:00 +0000

Authors: Lukas Fisch, Ramona Leenings, Nils R. Winter, Udo Dannlowski, Christian Gaser, James H. Cole, Tim Hahn

DOI: https://doi.org/10.3389/fpsyt.2021.710932

Local brain-age: A U-Net model

Fri, 01 Jan 2021 00:00:00 +0000

Authors: Sebastian G. Popescu, Ben Glocker, David J. Sharp, James H. Cole

DOI: https://doi.org/10.1101/2021.01.26.428243

Mind the gap: performance metric evaluation in brain-age prediction

Fri, 01 Jan 2021 00:00:00 +0000

Authors: Ann-Marie G. de Lange, Melis Anatürk, Jaroslav Rokicki, Laura K.M. Han, Katja Franke, Dag Alnæs, Klaus P. Ebmeier, Bogdan Draganski, Tobias Kaufmann, Lars T. Westlye, Tim Hahn, James H. Cole

DOI: https://doi.org/10.1101/2021.05.16.444349

Network Modeling Sex Differences in Brain Integrity and Metabolic Health

Fri, 01 Jan 2021 00:00:00 +0000

Authors: Janelle T. Foret, Maria Dekhtyar, James H. Cole, Drew D. Gourley, Marie Caillaud, Hirofumi Tanaka, Andreana P. Haley

DOI: https://doi.org/10.3389/fnagi.2021.691691

Rapid processing and quantitative evaluation of multicontrast EPImix scans for adaptive multimodal imaging

Fri, 01 Jan 2021 00:00:00 +0000

Authors: František Váša, Harriet Hobday, Ryan A. Stanyard, Richard E. Daws, Vincent Giampietro, Owen O’Daly, David J. Lythgoe, Jakob Seidlitz, Stefan Skare, Steven C. R. Williams, Andre F. Marquand, Robert Leech, James H. Cole

DOI: https://doi.org/10.1101/2021.02.12.430956

Rapid processing and quantitative evaluation of structural brain scans for adaptive multimodal imaging

Fri, 01 Jan 2021 00:00:00 +0000

DOI: https://doi.org/10.1002/hbm.25755

An automated machine learning approach to predict brain age from cortical anatomical measures